Download Renal Disease: Techniques and Protocols by Ellen M. Levee (auth.), Michael S. Goligorsky MD, PhD (eds.) PDF

By Ellen M. Levee (auth.), Michael S. Goligorsky MD, PhD (eds.)

Today's investigator, crushed via the data avalanche, could locate it tricky to research rising advances in know-how. In Renal sickness: innovations and Protocols, prime specialists distill their adventure into undemanding equipment for learning fluid-electrolyte homeostasis and kidney functionality in health and wellbeing and sickness. defined in step by step element, the options circulate from the molecular point to the full organism, and from basic versions to integrative body structure. the following the researcher will locate proven ailment versions, equipment for optimizing renal illness examine, in addition to a lot assist in identifying imaging ideas for reports of the kidney's constitution and serve as in healthiness, sickness, and through embryonic improvement. matters lined contain molecular diagnostics, suggestions for learning the molecular mechanisms of kidney ailment, technical skill to evaluate the sensible correlates of affliction, and the making plans of scientific trials. as well as distinct directions, every one state-of-the-art procedure contains troubleshooting suggestion, lists of reagents, and pointers on fending off pitfalls.
state of the art and hugely sensible, Renal sickness: innovations and Protocols is not just a vade mecum for the various strategies hired to review the kidney in health and wellbeing and illness this present day, but in addition a effortless consultant for the uninitiated, and a considerate seek advice for the skilled researcher.

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9, 2617–2627. 28 Upadhya 41. , Markowitz, G. , D’Agati, V. , Factor, S. , et al. (2000) Cardiac defects and renal failure in mice with targeted mutations in Pkd2. Nat. Genet. 24, 75–78. 42. Sullivan, L. , Wallace, D. , and Grantham, J. J. (1998) Epithelial transport in polycystic kidney disease. Physiol. Rev. 78, 1165–1191. 43. Lechner, M. S. and Dressler, G. R. (1997) The molecular basis of embryonic kidney development. Mech. Dev. 62, 105–120. Models of Metabolic Syndrome 29 3 Rat Models of the Metabolic Syndrome Stevan P.

Et al. (1996) PKD2, a gene for polycystic kidney disease that encodes an integral membrane protein. Science 272, 1339–1342. 5. Ward, C. , Hogan, M. , et al. (2002) The gene mutated in autosomal recessive polycystic kidney disease encodes a large, receptor-like protein. Nat. Genet. 30, 259–269. 6. Peters, D. J. and Breuning, M. H. (2001) Autosomal dominant polycystic kidney disease: modification of disease progression. Lancet 358, 1439–1444. 7. , and Mucher, G. (1998) Autosomal recessive polycystic kidney disease.

In the following section, we summarize our experience with this model. 3. 1. Dyslipidemia An important feature of the metabolic syndrome and a cardinal phenotype of the male obese ZSF1 rat is abnormally high plasma levels of cholesterol and triglycerides. In this regard, male obese ZSF1 rats are similar to male obese SHHF/Mcc-facp rats, and both of these strains have much higher cholesterol and triglyceride levels compared with male SHR, WKY, lean SHHF/Mcc-facp or lean ZSF1 rats (20). Table 1 compares plasma lipid levels in male obese ZSF1 vs male lean ZSF1 at various ages.

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