Download Comparative Physiology of the Vertebrate Kidney by William H. Dantzler PDF

By William H. Dantzler

This quantity emphasizes the comparative method of less than­ status vertebrate renal functionality. i'm confident that this method is of specific worth in realizing either the main points of renal functionality on the mobile and subcellular degrees and the renal position in regulating fluid volumes and solute concentrations. My publicity to this method first happened in the course of a scholar study event within the laboratory of Wilbur H. Sawyer, who additionally supplied an creation to the works of Homer W. Smith and August Krogh. the significance of this procedure was once strengthened by means of doctoral and postdoctoral learn within the laboratory of Bodil Schmidt-Nielsen. it's been proven via years of private adventure due to the fact then. My examine and my knowing of renal functionality were aided over the years via collaboration and dialogue with various scholars and colleagues. Of specific impor­ tance in constructing my perspectives on comparative renal functionality, and particularly at the dating of constitution to operate, has been my lengthy organization with my colleague and buddy, Eldon J. Braun. Donald S. Farner, who instructed the writing of this quantity, supplied useful editorial tips. a lot of my own study during this zone has been supported through the years by means of supplies from the us nationwide technology beginning and nationwide Institutes of health and wellbeing. The writing of this quantity used to be accomplished whereas i used to be in Wiirzburg, Federal Republic of Germany, supported by means of a Senior U.S. Scientist Award from the Alexander von Humboldt Foundation.

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Studies involving Alcian blue injections into stenohaline freshwater teleosts (Prussian carp, Carassius auratus gibelio) transferred to isosmotic seawater indicate that, during the first 2 hours of adaptation, many glomeruli are no longer perfused with blood (Elger et al. 1984). With prolonged adaptation to this medium, however, the survivors actually show atrophy and loss of many glomeruli (vide supra) (Elger and Hentschel 1981). Regulation of whole-kidney GFR by the regulation of the number of glomeruli filtering appears to be a practical adaptation for fishes, amphibians, 41 and reptiles in which the nephrons empty at right angles into collecting ducts and are not arranged to function in concert to produce a urine hyperosmotic to the plasma.

13 (71) Alt et al. 3 (9) Moriarty et al. 1978 Logan et al. 12 (3)" 5% filtering Brown et al. Brown et al. Brown et al. Brown et al. H. 7 (4)" Laverty and Dantzler 1982 Brenner et al. 1971 Trinh-Trang-Tan et al. 1981 Values are means ± SE. Figures in parentheses indicate number of determinations except in the case of the trout and rats where they indicate number of animals. "SNGFR's determined by constant infusion sodium ferrocyanide technique. All other determinations of SNGFR were made by micropuncture techniques.

The brush border is dense and high. b P2 segment. The cellular interdigitation is decreased; apically the cells have a smooth. outline. The brush border is less dense and reduced in height. Peroxysomes (cross-hatched profiles) are numerous. c and d P3 segments. The cellular interdigitation is drastically reduced. Regarding the brush border, considerable interspecies differences occur. In rabbit (c), as in most species, microvilli are scanty and short. In contrast, in rat (d) the brush border of P3 is the highest among all proximal segments.

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