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K Hoppe, B Gassmann. Neue Aspekte der Su¨sskraftbeurteilung und des Einsatzes von Su¨ssungsmitteln. Nahrung 24:423, 1980. 11. S. 1979) to Hoechst AG. 12. RA Frank, SJ Mize, R Carter. An assessment of binary mixture interactions for nine sweeteners. Chem Senses 14:621, 1989. 13. N Ayya, HT Lawless. Quantitative and qualitative evaluation of high-intensity sweeteners and sweetener mixtures. Chem Senses, 17:245, 1992. 14. G-W von Rymon Lipinski, E Klein. Synergistic effects in blends of Acesulfame K and Aspartame.

After prolonged exposure to acesulfame K, animals did not show any sign of induced metabolism. Again, after administration of 14 Clabeled acesulfame K, only the original substance was found in the excreta (22). Acesulfame K is not metabolized by bacteria. This applies, too, for Streptococcus mutans and other microorganisms that may contribute to the formation of caries. Acesulfame K was tested in several studies. Although an inhibition of dental plaque microorganisms or S. mutans was not always reported, in other test systems a clear inhibition was demonstrated (27–29).

SAFETY Alitame has been evaluated in the extensive series of studies designed to establish its safety as a sweetener in the human diet. A list of the major studies completed is shown in Table 4. On the basis of substantial safety factors determined in these studies, it is concluded that alitame is safe for its intended use as a component of the diet of man. The appropriateness of the animal studies is supported by the fact that the major metabolites of the compound are common to laboratory animals and man.

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