By CIBA Foundation Symposium
Many alternative pathological stipulations are at the moment below research as healing ambitions of purines together with melanoma, cardiovascular stipulations, behavioural issues, irritation, immunoregulation, and neuroendocrine functionality. This ebook attracts jointly study on all elements of P2 purinoceptors and discusses their use in several healing parts.
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Extra info for Ciba Foundation Symposium 198 - P2 Purinoceptors: Localization, Function and Transduction Mechanisms
Goode Copyright 0 1996 by Ciba Foundation The diadenosine polyphosphate receptors: P2D purinoceptors M. Teresa Miras-Portugal, Enrique Castro, Jesus Mateo and Jesus Pintor Departamento de Bioquimica, Facultad de Veterinaria, Universidad Cornplutense, E-28040 Madrid, Spain Abstract. Diadenosine polyphosphates-Ap,A, Ap,A and Ap,A-are co-stored in ncurosecretory vesicles together with ATP and aminergic compounds. They are released from neural cells and synaptic terminals in a Ca2+-dependent process.
Eur J Pharmacol 165:323-326 Hourani SMO, Hall DA, Nieman CJ 1992 Effects of the P2-purinoceptor antagonist, suramin, on human platelet aggregation induced by adenosine 5’-diphosphate. Br J Pharmacol 105:453457 Housely G D , Greenwood D, Bennett T, Ryan A F 1995 Identification of a short form of the P2xRI-purinoceptor subunit produced by alternative splicing in the pituitary and cochlea. Biochem Biophys Res Commun 212:501-508 Hoyle CHV, Burnstock G 1991 ATP receptors and their physiological roles.
The P2Y I receptor, at least, therefore recognizes both the Mg2+-complexed and the uncomplexed forms of ATP. The same has been shown to hold in the binding of a,$methylene ATP to the P2X receptor type in vas deferens membranes (Michel & Humphrey 1994). + Perspective 33 Surprenant: Our discussions concerning neural release of purines all assume that it is ATP rather than adenosine that is released. But what is the direct evidence that this is the case? Burnstock: It’s clear enough in the periphery; adenosine is taken up by neurons and converted largely to ATP.