Download Ciba Foundation Symposium 196 - Growth Factors as Drugs for by CIBA Foundation Symposium PDF

By CIBA Foundation Symposium

Degeneration of sensory receptors or of the nerves innervating them results in a sensory deficit. numerous thoughts were attempted for selling regrowth of sensory receptors, rather within the eye and ear. the most recent info from experimental stories in animals are offered within the e-book together with purposes of BDNF and CNTF within the eye and epidermal development think about the ear.

Content:

Show description

Read Online or Download Ciba Foundation Symposium 196 - Growth Factors as Drugs for Neurological and Sensory Disorders PDF

Best mammals books

The Ecology of Browsing and Grazing

Large grazing and perusing by way of household and wild herbivores form the plants composition, constitution and dynamics of many terrestrial ecosystems. This quantity investigates how huge herbivores not just effect the constitution and distribution of the plants, but additionally have an effect on nutrient flows and the responses of linked fauna.

Among the Islands: Adventures in the Pacific

Tim Flannery is without doubt one of the world’s so much influential scientists, credited with learning extra species than Darwin. In one of the Islands Flannery recounts a sequence of expeditions he made on the sunrise of his profession to the unusual tropical islands of the South Pacific, an excellent arc stretching approximately 4,000 miles from the postcard perfection of Polynesia to a few of the biggest, optimum, historical, and so much rugged islands in the world.

Wildlife Monographs - Wolves

There are likely extra myths and legends approximately wolves than the other dwelling creature. In fiction, they're normally portrayed as evil yet during this e-book the authors set out, in phrases and photographs, to supply a clearer and un-prejudiced realizing of the lives of those carnivorous mammals their heritage, behavior, distribution, atmosphere and their organization with guy, himself a hunter.

Additional resources for Ciba Foundation Symposium 196 - Growth Factors as Drugs for Neurological and Sensory Disorders

Example text

Neurotrophins and neurotrophin-CNTF combination 41 Specificity of NT-3 for proprioceptive sensory neurons and efficacy of NT-3 in an animal model of large fibre sensory neuropathy Specijicity of NT-3 f o r developing proprioceptive sensory neurons As one of the first neurotrophic factors to be discovered by a homology cloning strategy, nothing was known about the function of NT-3 prior to its expression as a recombinant protein. Thereafter, however, it was rapidly established that the neuronal specificity of NT-3 was both overlapping and distinct from that of N G F or BDNF.

Vuught: Some trivial explanations of its activity would be that it is an NMDA antagonist, or it binds to an adenosine site, or it’s affecting voltagegated Ca2+ channels, for example. We have found no effect on these systems. There’s some other mechanism involved in its neuroprotective-like activity on these systems. We’ve looked at this in great detail. We don’t believe we’ve found a new system; CEP-1347 simply taps into an existing system. It doesn’t appear to involve Ras. On administration of this molecule to SY5Y cells, we see a phosphorylation of two major bands of p140 and p125.

Although BDNF itself is capable of promoting the survival of more than 90% of embryonic motor neurons in culture (Henderson et al 1993), we found 44 Lindsay striking synergistic actions of BDNF and CNTF towards motor neurons by examining the effects of each factor and combinations of both factors on the induction of choline acetyltransferase (ChAT) (Wong et a1 1993). Individually, each factor was found to increase ChAT levels by two- to threefold, but the effect of co-treatment with both factors was significantly more than additive (Wong et a1 1993).

Download PDF sample

Rated 4.13 of 5 – based on 13 votes