By Robert E. Becker (auth.), Robert Becker, Ezio Giacobini (eds.)
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Extra resources for Cholinergic Basis for Alzheimer Therapy
Brain Research 517:19-24. Part I. Cholinesterases: Anatomy, Pathology and Human Genetics CORTICAL CHOLINESTERASES IN ALZHEIMER'S DISEASE: ANATOMICAL AND ENZVMATIC SHIFfS FROM THE NORMAL PATTERN M-Marsel Mesulam and Changiz Geula Bullard and Denny-Brown Laboratories, Division of Neuroscience and Behavioral Neurology, Harvard Neurology Department and the Dana Research Institute of the Beth Israel Hospital, 330 Brookline Avenue, Boston, MA The great majority of cortical cholinesterase activity in the normal brain is expressed in the form of axonal and perikaryal acetylcholinesterase (AChE).
We do not know whether these enzymes identify independent populations of plaques and tangles or whether there is also some coexistence of the two enzymes. , 1990). It is interesting to note that each of these inhibitors was 10 to 100 times more potent for inhibiting the cholinesterase& of normal cholinergic fibers than the cholinesterase& of plaques and tangles. 0 for the AChE and BChE associated with plaques and tangles. It appears, therefore, that the enzymatic properties of cholinesterase& in plaques and tangles show substantial shifts when compared to the cholinesterase& of the normal brain.
Chatonnet A and Masson P (1985): Study of the peptidasic site of cholinesterase: preliminary results. FEBS 182:493-498. Davis KL, Mobs RC, Tinklenberg JR et al. (1978): Physostigmine: enhancement of long-term memory in normal subjects. Science 201:272274. Geula C and Mesulam M-M (1989): Special properties of cholinesterases in the cerebral cortex of Alzheimer's disease. Brain Res 498:185-189. Heilbronn E (1961): Inhibition of cholinesterases by tetrahydroaminoacridine. Acta Chem Scand 15:1386-1390.