Download Biology of the Mouse Histocompatibility-2 Complex: by Jan Klein (auth.) PDF

By Jan Klein (auth.)

Somewhere I heard a narrative of a bridge and a painter. The bridge used to be huge, immense and was once made all of steel, and the painter's activity was once to maintain it from rusting. He may commence at one finish and slowly continue, day-to-day, month through month, towards the opposite finish, portray the bridge. yet no quicker could he end with the portray than the bridge could start to rust back. The rust, too, could commence at one finish and slowly continue towards the opposite finish, systematically destroying the painter's exercise. And so the painter may go back to the place he had began, and start portray back, slowly continuing towards the opposite finish of the bridge, regularly only one step prior to the rust. And if the tale is right, the painter may perhaps nonetheless be portray that bridge-a sleek Sisyphus! throughout the writing of this publication, the tale of the painter and his bridge stored coming to brain. the sphere the booklet covers has been constructing so quickly that, just like the painter, I too needed to go back to the place I had all started and struggle the rust of obsolescence. yet not like the painter, I had a cut-off date to fulfill, which constituted some extent of no go back. And so, sending off this manuscript, i've got no selection yet to monitor the culmination of my recreation be overtaken via the rust.

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Read or Download Biology of the Mouse Histocompatibility-2 Complex: Principles of Immunogenetics Applied to a Single System PDF

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Extra info for Biology of the Mouse Histocompatibility-2 Complex: Principles of Immunogenetics Applied to a Single System

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III. Domesticated Mice Domesticated M. musculus are mice that have been deliberately adapted to life in captivity. The earliest domesticated mice were bred for fancy, particularly in ancient China and Japan, where pet fanciers collected rare variants of mice and kept them for entertainment. The hobby of breeding fancy mice was brought by British traders to Europe, and from there eventually spread to the United States. In the second half of the nineteenth century, domesticated mice found their way into the laboratories and became favorite experimental animals in many areas of research.

Bailey (1971) suggests at least four different experimental applications of the RI strains: I. Identification of histocompatibility (H) loci. When a new H locus is isolated in a congenic line, its relationship to the loci already known can be quickly determined by comparing their respective SDP's. 2. Search for H gene function. It is assumed that the H genes have functions other than graft rejection. The RI inbred strains may facilitate search for the function by pointing to an association between certain physiological characters and the presence or absence of a particular H allele.

6 from the F 1 hybrids (in this particular situation the donor strain must also be inbred). For further matings, animals rejecting the skin grafts most rapidly are used. These animals are presumed to differ from the F 1 hybrid more than those showing prolonged survival of the F 1 grafts and thus to resemble closely the background strain. If an unknown H-2 haplotype is being introduced into a background strain and antiserum against this type is not available, the backcross system must be modified.

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