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Number of psychiatric disorders, including bipolar affective disorder, subThis particular association is exciting stance abuse and chronic conduct problems. Studies by COGA consortium because it confirms part of a hypothesis armembers have demonstrated that variants of the GABRA2 gene are linked ticulated in 1976 by psychiatrist David to alcoholism, a finding that has since been confi rmed by at least four groups. Janowsky and his colleagues at Vanderbilt Interestingly, these variations in GABRA2 do not change the protein strucUniversity regarding the brain’s need to ture of the GABA A receptor; instead they seem to modify production of the maintain a fi ne balance between different affected protein subunit, perhaps reducing the total number of functioning signal-regulating processes to function norreceptors.

To generate plasmons that can propagate through nano scale wires, researchers have explored more complex waveguide geometries that can shrink the wavelength of the signal by squeezing it into a narrow space. In the late 1990s my lab group and a team led by Joachim Krenn of the University of Graz in Austria launched parallel efforts to produce these “subwavelength” surface-plasmon waveguides. Working with me at Caltech, Stefan Maier built a structure consisting of linear chains of gold dots, each less than 100 nanometers across.

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