Download Aplastic Anemia: Pathophysiology and Approaches to Therapy by H. Heimpel (auth.), Hermann Heimpel M. D., Edward C. PDF

By H. Heimpel (auth.), Hermann Heimpel M. D., Edward C. Gordon-Smith M. D., Wolfgang Heit M. D., Bernhard Kubanek M. D. (eds.)

Research on aplastic anaemia has till lately been constrained to medical description, morphology and epidemiology. New the right way to tradition haemopoietic cells, and advances in our wisdom of proliferation and differentiation within the haemopoietic mobilephone process .opened a brand new zone of clinical curiosity for this "prototype" of haemopoietic failure. moreover, bone marrow transplantation grew to become not just a scientific approach to remedy, but additionally a resource of knowledge beneficial for the dialogue of pathophysiological types of aplastic anaemia. this case caused us to rearrange a world con­ ference on aplastic anaemia, with specific emphasis on its patho­ body structure and the rationals of the present healing methods. This convention used to be held at Schloss Reisensburg from July 20-22, 1978 with the participation of either experimental and medical scientists energetic during this box or in similar parts of study. The complaints of the symposion mirror the current wisdom in addition to the various new questions which arose from the discussions. The editors are gratefully indebted to the individuals of this assembly, to Gerlinde Trogele and all of the co-workers of the Uni­ versity of Ulm engaged in training of this symposium and of this quantity, and final now not least to all sponsors who supplied the monetary foundation for this clinical event.

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Extra info for Aplastic Anemia: Pathophysiology and Approaches to Therapy

Sample text

The age composition of the eastern data is entirely different from that of the western. , 80 per cent of the patients with aplastic anemia are above 50 years of age [4]. Whang [14] from Korea has collected a large data of patients with aplastic anemia - only 12 per cent were above 50 years. This is a highly significant difference. The age composition is different, however, not only with regard to the oldest age groups - as shown in Figure 1 the Korean material has a very marked peak between 10 and 40 years of age.

There is evidence linking viral infections with damage to each of these tissues. Nevertheless, it has been difficult to correlate specific viral infections with development of marrow aplasia. In this paper evidence implicating viruses in the etiology of aplastic anemia is reviewed. There is good, though incomplete, data linking infectious hepatitis viruses and marrow aplasia in mice and man. There is currently little evidence that other viral infections playa role in the pathogenesis of human aplastic anemia.

114, 687-690 (1963) 22. Karp, J. , Schacter, L. , Burke, P. : Humoral factors in aplastic anemia: Relationship of liver dysfunction to lack of serum stimulation of bone marrow growth in vitro. Blood 51, 397-414 (1978) 23. Kivel, R. : Hematologic aspectsofacute viral hepatitis. Am. J. Dig. Dis. 6, 1017-1031 (1961) 24. , Lang, D. : Leukocyte mitosis. Suppression in vitro associated with infectious hepatitis. Science 155,80-81 (1967) 25. Miesch, D. , Levin, W. : Acute erythroblastopenia: Pathogenesis, manifestations and management.

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