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By W.E. Barnes

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Clinical San Francisco: American Academy of Ophthalmology; Modules for 2002, module II. Oph- 26 . Ophthalmic Pathology and Intraocular Tumors lens Small rents in the lens capsule are sealed by nearby lenticular epithelial cells. When posterior synechiae make the lenticular epithelium anoxic or hypoxic, a metaplastic response occurs, producing fibrous plaques intermixed with basement membrane. Retina The retina is made of permanent cells that do not regenerate when fatally injured. Instead, a glial plug pulls the retina together after closure.

Mislabeling of pathology specimens or reports through a simple typing error, for example, can have serious consequences. Merely correcting the patient age on the pathology request form may change the interpretation of melanotic lesions of the conjunctiva. Benign pigmental melanotic lesions in children may have a similar histologic appearance to malignant melanotic lesions in adults. Whether the patient is age 4 or age 44 makes a tremendous difference in interpretation. Finally, the ophthalmologist who makes an effort to consult with the pathologist prior to surgery sends a clear signal both of special interest in the case and of respect for the contribution of the pathologist.

Giant cells formed from histiocytes come in several varieties, including . . Langhans cells, characterized by a horseshoe arrangement of the nuclei (Fig 1-9) Touton giant cells, which have an annulus of nuclei surrounded by a lipid-filled clear zone (Fig 1-10) foreign body giant cells, with haphazardly arranged nuclei (Fig 1-11) Lymphocytes are small cells with round, hyperchromatic nuclei and scant cytoplasm. Circulating lymphocytes infiltrate tissue in all types of chronic inflammatory processes.

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