Download Aging and Drug Therapy by I. H. Stevenson (auth.), G. Barbagallo-Sangiorgi, A. N. PDF

By I. H. Stevenson (auth.), G. Barbagallo-Sangiorgi, A. N. Exton-Smith (eds.)

One of the best advances in Geriatric drugs over the last sector of a century has been the elevated awareness of the probabilities of therapy for aged sufferers. overlook has been changed by way of a extra positive healing endeavour and numerous outdated humans have benefitted from this process. yet there's additionally a disadvantage, and this is often the chance of damaging uncomfortable side effects of drugs that are usually at once proportional to the organic efficiency of the drug and will be unpredictably elevated because of adjustments within the senile organism. actually the anatomical and organic alterations in previous age regulate either the kinetics of so much medicines and the receptor reaction. as a result of those alterations the person tolerance of elderly sufferers to drug remedy might be rather various from that of more youthful matters. therefore for quite a few purposes aged sufferers obtain extra medicinal drugs, yet they're at a better hazard of encountering opposed reactions, which regularly exhibit bizarre scientific positive aspects. we will be able to for that reason converse of "geriatric iatrogenic problems" and indicate that a few of these uncomfortable side effects are made up our minds by means of a posh pathogenesis as a result of specific pathophysiological within the aged. it is very important inspire the behavior of individ­ ually comparing capability danger as opposed to anticipated merits of gear in line with a similar ideas followed within the overview of cost/benefit ratio.

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Di Sciacca, G. Frada Jr, G. Cupidi, M. Barbagallo, II danno jatrogenico da farmaci, Nuovo Boll. Clin. 3:157 (1981). G. Barbagallo Sangiorgi, A. Di Sciacca, G. Frada Jr, R. Malta, C. Geront. 29:391 (1981). G. Barbagallo Sangiorgi, A. Di Sciacca, A. Pardo, Potassium depletion in aged patients; an evaluation through red-bloodcell potassium determination, Age & Ageing 8:190 (1979). 40 8. 9. 10. 11. 12. 13. 14. 15. 16. 17. 18. 19. 20. 21. G. B. SANGIORGI G. J. Caranasos, R. B. Stewart, L. E. Ass. 228:713 (1974).

In fact in most cases these problems concern drugs whose purpose IS to treat ailments or diseases which may determine loss of selfsufficiency. The decision to discontinue such treatment may therefore involve greater risks than the decision to continue them. The purpose of the present lecture is to try to determine which symptoms may be suspected as due to iatrogenic effects and which guidelines should be followed to identify such pathological conditions. I will not deal with some symptoms which are easily identified and do not show essential differences when compared to those occurring in other ages of life, such as allergic syndromes and cutaneous symptoms, whose clinical features are similar in all ages of life, as well as disorders of the bladder or of the eyes due to administration of anticholinergic drugs.

7. R. O. Friedel, Introduction to the satellite symposium to the XII International Congress of Gerontology, Bremen, July 10-11 1981: Influence of old age on the effect of drugs, Gerontoly 28:5 (1982). N. B. l) S. Karger, Basel (1982). M. C. Pharmacother. 3:69 (1980) . J. Crooks, J. Shepherd, I. Stevenson, Health Bulletin, 33:222 (1975). K. O'Malley, T. Judge, J. Crooks, Drug treatment, in: "Principles and Practice of Clinical Pharmacology and Therapeutics," G. S. , Adis Press, Sydney (1976). R.

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